Glenmark Pharmaceuticals to present data from Phase 2a study of ‘GBR 830’ at the Fall Clinical Dermatology Conference
Deepthi | Myequity news | Date : 19-10-2018 12:10:00 IST
Glenmark Pharmaceuticals to present encore data from a Phase 2a, proof-of-concept study of GBR 830, an investigational treatment in development for moderate-to-severe atopic dermatitis (AD), at the Fall Clinical Dermatology Conference in Las Vegas. The poster, GBR 830 induces progressive and sustained improvements in atopic dermatitis skin biomarkers and clinical parameters, describes findings from this exploratory study, including evaluation of safety and the effect of the investigational drug on AD biomarkers, and provides the first clinical evidence of biological activity.
Mahboob Rahman, President and Chief Medical Officer at Glenmark Pharmaceuticals said, “Presentation of these data from a Phase 2a study of our lead biologic candidate, GBR 830, along with detailed ex vivo studies that elucidate its mechanism, is part of our continued commitment to further analyze and characterize the unique profile and activity of this potential treatment for atopic dermatitis. We look forward to sharing further updates in the future, as the current and ongoing Phase 2b trial of GBR 830 progresses.” About GBR 830 in Atopic Dermatitis:
In addition, a second poster entitled, Targeting OX40 with GBR 830, an OX40 antagonist, inhibits T cell-mediated pathological response, is being presented at the meeting. The poster describes data suggesting that GBR 830 has immunomodulatory capabilities in memory/chronic T helper cell-mediated pathological responses with no impact on primary antibody responses.
GBR 830 is an investigational monoclonal antibody designed to inhibit OX40, a costimulatory immune checkpoint receptor expressed on activated T cells and memory T cells. Costimulatory signals are essential for T cell activity, and binding between OX40 and OX40L is a biomarker for the severity of autoimmune diseases. The activation of this pathway leads to conversion of activated T cells into memory T cells, which promotes inflammation. In addition, regulatory T cells also contribute to inflammation, and OX40 signaling by these cells down regulates immune suppressing functions. It is believed that GBR 830 may inhibit the dual activities of OX40 and OX40L binding in both activated T cells and regulatory T cells, thus potentially reducing inflammation associated with symptoms of atopic dermatitis. About Glenmark Pharmaceuticals:
Glenmark Pharmaceuticals Ltd. (GPL) is a global innovative pharmaceutical company with operations in more than 50 countries. Glenmark has a diverse pipeline with several compounds in various stages of clinical development, primarily focused in the areas of oncology, respiratory disease and dermatology. Glenmark has improved the lives of millions of patients by offering safe, affordable medications for nearly 40 years.